… ET A R and ET B R, inducing their growth, migration, contraction and production of proteins
… CTGF is required for ET-1-induced alpha-smooth muscle actin (α-SMA) expression [94]. …

… In pulmonary artery SMCs, endothelin-1-induced increase in … levels of endothelin receptors
type A (ETA) and B (ETB). In … 7 mol/L) did not alter endothelin receptor (ETA and ETB) mRNA …

… Rho kinase mediates Ca 2+ sensitization in smooth muscle cells; it phosphorylates MYPT, a
… known to be involved in ET-1-induced contraction of smooth muscle [24]. We confirmed the …

… The functional contractile component of the ET B receptor in vascular smooth muscle … indoxyl
sulfate would induce ET B receptor function in vascular smooth muscle, we next examined …

… contraction by increasing Ca 2+ signalling. Increased Ca 2+ via ET B receptors also contribute
to contractions … 2+ influx in pulmonary vascular smooth muscle, 22 and mesangial cells. …

… role of ET-1 receptors, ET A and ET B in the regulation of … The role of ET A and ET B receptors
in regulating RhoA/… -1 and with selective ET A and ET B receptor antagonists. ET-1 infusion …

… During an acute exacerbation, excessive contraction of airway smooth muscle (ASM) that …
To address this knowledge gap, we focused on endothelin-1 (ET-1) that is secreted from …

… contraction, signalling and mechanisms of receptor activation. … The contractile response to
angiotensin II and endothelin-1 … ERK1/2 from rat vascular smooth muscle cells stimulated with …

… by binding to EDNRA expressed by vascular smooth muscle cells, which are abundant in …
mural cells, which elicits contraction of vascular smooth muscle cells and consequential …

… mice with endothelin-1. Compared to IsoPE, treatment with endothelin-1 induced minor but
… These were predominantly associated with regulation of smooth muscle cell proliferation (…